Are the SATA power connectors on motherboards compatible with both 2.5 & 3.5 drives?

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Are the SATA power connectors on motherboards compatible with both 2.5 & 3.5 drives?

I want to switch my desktops internal 3.5 in drives to 2.5 in drives. I know that the signal cables are the same, but does that apply to the power connections too?

Is it safe?
 
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