Eyefinity supports 3 monitors on the same card (depending on the model) - mine has 2xDVI and 1xDisplayPort. Plug in monitors and go (I am not sure how much configuration is needed in CCC)
I think that ATI are very fast but software and compatibility are an issue. I think that when I will be getting new graphic card it will be definitely Nvidia, but have to be at leas 200% faster then my current Nvidia GTX280. Just like with CPU will not change it antill the will have something 200% faster then my current Quad q9550. No point to change for anything else.